• Get plenty of rest. You may need bed rest, which could keep you away from school or work for a little while.
• Gargle with salt water or use throat lozenges to soothe your sore throat.
• Take acetaminophen (such as Tylenol) or ibuprofen (such as Advil) to reduce fever and relieve a sore throat and headaches.
• Avoid contact sports and heavy lifting. Your spleen may be enlarged, and impact or straining could cause it to burst.

In severe cases, medicines called corticosteroids may be used to reduce swelling of the throat, tonsils, or spleen.